In the pharmaceutical industry microencapsulation is often used for drug delivery. A better therapeutic effect, fewer side effects and higher patient convenience / compliance are achieved by means of controlled and sustained release of the Active Pharmaceutical Ingredient (API). Other applications are the delivery of poorly soluble APIs, taste masking, targeted delivery and stability improvement.
Droplet production with the use of microchannels, otherwise called microfluidic emulsification, is a much reported method to make uniform and controlled soft matter structures, like emulsions, microcapsules and microspheres. The process takes place in channels of only a few microns wide. Once droplets are formed they can be solidified in the channel by extracting the solvent or adding a third liquid, such as a cross-linker.
The heart of the Emultech platform is Emultech's unique mathematical model. The model ensures easy operation and helps you to quickly identify the right process conditions to obtain the desired results. Furthermore, the model guarantees high batch-to-batch consistency and easy translation from the Emultech D to the Emultech P and scaling up to clinical and market relevant volumes.
The Emultech platform is ready for customers to produce their samples under (sterile) cGMP conditions. The equipment is easily made aseptic for sterile production without the need for end-sterilisation. All the wetted components in these closed setups can be autoclaved and 0.22 micron filters ensure sterile liquids. The capabilities for sterile production have already be confirmed in dozens of sterile productions for preclinical in vivo samples.